Distinct Transcriptomic Cell Types and Neural Circuits of the Subiculum and Prosubiculum along the Dorsal-Ventral Axis

• DOI: 10.1016/j.celrep.2020.107648
• Publication Date: 2020-05-19T14:49:29Z
• Authors: Song-Lin Ding; Zizhen Yao; Karla E. Hirokawa; Thuc Nghi Nguyen; Lucas T. Graybuck; Olivia Fong; Phillip Bohn; Kiet Ngo; Kimberly A. Smith; Christof Koch; John W. Phillips; Ed S. Lein; Julie A. Harris; Bosiljka Tasic; Hongkui Zeng
• Keywords: Subiculum; Biological neural network; Nerve net

Subicular regions play important roles in spatial processing and many cognitive functions, these are mainly attributed to the subiculum (Sub) rather than prosubiculum (PS). Using single-cell RNA sequencing, we identify 27 transcriptomic cell types residing sub-domains of Sub PS. Based on situ expression reliable markers, precise boundaries PS consistently defined along dorsoventral axis. borders evaluate Cre-line specificity tracer injections, find bona fide projections topographically structures for navigation. In contrast, sends its outputs widespread brain crucial motivation, emotion, reward, stress, anxiety, fear. The PS, respectively, dominate dorsal ventral subicular receive different afferents. These results reveal two molecularly anatomically distinct circuits centered providing a consistent explanation historical data clearer foundation future studies.