Human Immune System Variation during 1 Year

• DOI: 10.1016/j.celrep.2020.107923
• Publication Date: 2020-07-21T14:39:26Z
• Authors: Tadepally Lakshmi...; Sayyed Auwn Muhammad; Axel Olin; Yang Chen; Jaromir Mikes; Linn Fagerberg; Anders Gummesson; Göran Bergström; Mathias Uhlen; Petter Brodin
• Keywords: Antigenic variation; Variation (astronomy)

The human immune system varies extensively between individuals, but variation within individuals over time has not been well characterized. Systems-level analyses allow for simultaneous quantification of many interacting components and the inference global regulatory principles. Here, we present a longitudinal, systems-level analysis in 99 healthy adults 50 to 65 years age sampled every third month 1 year. We describe structure interindividual characterize extreme phenotypes along principal curve. From coordinated measurement fluctuations, infer relationships 115 cell populations 750 plasma proteins constituting blood system. While most have stable systems, degree longitudinal variability is an individual feature. variable absence overt infections, exhibited differences markers metabolic health suggestive possible link immunologic homeostatic regulation.