Brown Adipose Expansion and Remission of Glycemic Dysfunction in Obese SM/J Mice

• DOI: 10.1016/j.celrep.2020.108237
• Publication Date: 2020-10-06T14:41:50Z
• Authors: Caryn Carson; Juan F. Macias-Ve...; Subhadra Gunawardana; Mario A. Miranda; Sakura Oyama; Celine L. St. Pierre; Heather Schmidt; Jessica P. Wayhart; Heather A. Lawson
• Keywords: Blood Glucose; Male; 2. Zero hunger; obesity; 0303 health sciences; QH301-705.5; mouse model; Article; Mice; 03 medical and health sciences; Adipose Tissue, Brown; 616; glycemic control; Animals; Humans; Female; Obesity; Biology (General); metabolism; transcriptome; brown adipose

We leverage the SM/J mouse to understand glycemic control in obesity. High-fat-fed mice initially develop poor glucose homeostasis relative controls. Strikingly, their dysfunction resolves by 30 weeks of age despite persistent The dramatically expand brown adipose depots as they resolve dysfunction. This occurs naturally and spontaneously on a high-fat diet, with no temperature or genetic manipulation. Removal depot impairs insulin sensitivity, indicating that expanded tissue is functioning an insulin-stimulated sink. describe morphological, physiological, transcriptomic changes occur during expansion remission dysfunction, focus Sfrp1 (secreted frizzled-related protein 1) compelling candidate may underlie this phenomenon. Understanding how contributes will open door for innovative therapies aimed at improving metabolic complications