Airway Microbiota-Host Interactions Regulate Secretory Leukocyte Protease Inhibitor Levels and Influence Allergic Airway Inflammation

• DOI: 10.1016/j.celrep.2020.108331
• Publication Date: 2020-11-03T20:23:26Z
• Authors: Natalia Jaeger; Ryan T. McDonough; Anne L. Rosen; Ariel Hernandez-L...; Naomi G. Wilson; Michael A. Lint; Emilie V. Russler...; Jiani N. Chai; Leonard B. Bacharier; Chyi-Song Hsieh; Andrew L. Kau
• Keywords: SLPI; Mucociliary clearance

Homeostatic mucosal immune responses are fine-tuned by naturally evolved interactions with native microbes, and integrating these relationships into experimental models can provide new insights human diseases. Here, we leverage a murine-adapted airway microbe, Bordetella pseudohinzii (Bph), to investigate how chronic colonization impacts immunity the development of allergic inflammation (AAI). Colonization Bph induces differentiation interleukin-17A (IL-17A)-secreting T-helper cells that aid in controlling bacterial abundance. protects from AAI is associated increased production secretory leukocyte protease inhibitor (SLPI), an antimicrobial peptide anti-inflammatory properties. These findings additionally supported clinical data showing higher levels upper respiratory SLPI correlate both greater asthma control presence Haemophilus, genus AAI. We propose could be used as biomarker beneficial host-commensal airway.