The ventral hippocampus CA3 is critical in regulating timing uncertainty in temporal decision-making

• DOI: 10.1016/j.celrep.2021.108694
• Publication Date: 2021-02-03T14:49:05Z
• Authors: Bilgehan Çavdaroğlu; Sadia Riaz; Yuqing Shi; Fuat Balcı; Rutsuko Ito
• Keywords: Escape response

Timing uncertainty is a critical component of temporal decision-making, as it determines the decision strategies that maximize reward rate. However, little known about biological substrates timing uncertainty. In this study, we report CA3 subregion ventral hippocampus (vCA3), relatively unexplored area in timing, regulating informs making. Using variant differential reinforcement low rates responding (DRL) task incorporates levels approach-avoidance conflict, rats were trained to wait minimum 6 s earn was paired with varying durations foot shock. Post-training chemogenetic inhibition vCA3 reduced without affecting mean times, irrespective level conflict experienced. Simulations based on information-processing scalar expectancy theory (SET) revealed may be important modulating threshold or switch closure latency variability.