Staphylococcus cohnii is a potentially biotherapeutic skin commensal alleviating skin inflammation

• DOI: 10.1016/j.celrep.2021.109052
• Publication Date: 2021-04-27T16:26:01Z
• Authors: Yoshihiro Ito; Takashi Sasaki; Youxian Li; Takeshi Tanoue; Yuki Sugiura; Ashwin N. Skelly; Wataru Suda; Yusuke Kawashima; Nobuyuki Okahashi; Eiichiro Watanabe; Hiroto Horikawa; Aiko Shiohama; Rina Kurokawa; Eiryo Kawakami; Hachiro Iseki; Hiroshi Kawasaki; Yoichiro Iwakura; Atsushi Shiota; Liansheng Yu; Junzo Hisatsune; Haruhiko Koseki; Motoyuki Sugai; Makoto Arita; Osamu Ohara; Takeshi Matsui; Makoto Suematsu; Masahira Hattori; Koji Atarashi; Masayuki Amagai; Kenya Honda
• Keywords: Commensalism

Host-microbe interactions orchestrate skin homeostasis, the dysregulation of which has been implicated in chronic inflammatory conditions such as atopic dermatitis and psoriasis. Here, we show that Staphylococcus cohnii is a commensal capable beneficially inhibiting inflammation. We find Tmem79−/− mice spontaneously develop interleukin-17 (IL-17)-producing T-cell-driven Comparative microbiome analysis reveals disease activity index negatively associated with S. cohnii. Inoculation strains isolated from either mouse or human microbiota significantly prevents ameliorates without affecting pathobiont burden. colonization accompanied by activation host glucocorticoid-related pathways induction anti-inflammatory genes therefore effective at suppressing inflammation diverse pathobiont-independent models, including chemically induced, type 17, 2 immune-driven models. As such, have great potential live biotherapeutics for