Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence

• DOI: 10.1016/j.celrep.2021.109362
• Publication Date: 2021-07-13T15:07:09Z
• Authors: Sara Kohnke; Sophie Buller; Danae Nuzzaci; Katherine Ridley; Brian Lam; Helena Pivonkova; Marie A. Bentsen; Kimberly M. Alonge; Chao Zhao; John Tadross; Staffan Holmqvist; Takahiro Shimizu; Hannah Hathaway; Huiliang Li; Wendy Macklin; Michael W. Schwartz; William D. Richar...; Giles S.H. Yeo; Robin J.M. Franklin; Ragnhildur T. Kar...; David H. Rowitch; Clemence Blouet
• Keywords: Median eminence; Progenitor; Homeostasis

The mediobasal hypothalamus (MBH; arcuate nucleus of the [ARH] and median eminence [ME]) is a key nutrient sensing site for production complex homeostatic feedback responses required maintenance energy balance. Here, we show that refeeding after an overnight fast rapidly triggers proliferation differentiation oligodendrocyte progenitors, leading to new oligodendrocytes in ME specifically. During this nutritional paradigm, perineuronal nets (PNNs), emerging regulators ARH metabolic functions, are remodeled, process requires myelin regulatory factor (Myrf) progenitors. In genetically obese ob/ob mice, regulations PNN remodeling blunted, enzymatic digestion local increases food intake weight gain. We conclude MBH PNNs balance lean mice remodeled adult by control differentiation.