Geographic differences in gut microbiota composition impact susceptibility to enteric infection

• DOI: 10.1016/j.celrep.2021.109457
• Publication Date: 2021-07-27T15:14:42Z
• Authors: Ana Maria Porras; Qiaojuan Shi; Hao Zhou; Rowan Callahan; Gabriella Montene...; Noel Solomons; Ilana Lauren Brito
• Keywords: Citrobacter rodentium; Gut microbiome

Large-scale studies of human gut microbiomes have revealed broad differences in composition across geographically distinct populations. Yet, examining impacts microbiome on various health outcomes typically focus single populations, posing the question whether compositional between populations translate into susceptibility. Using germ-free mice humanized with samples from 30 donors representing three countries, we observe robust susceptibility to Citrobacter rodentium, a model for enteropathogenic Escherichia coli infections, according geographic origin. We do not see similar responses Listeria monocytogenes infections. further find that cohousing most susceptible and resistant confers protection C. rodentium infection. This work underscores importance increasing global participation related outcomes. Diverse cohorts are needed identify both population-specific specific interventions achieve broader-reaching biological conclusions generalize