Age and the aging process significantly alter the small bowel microbiome

• DOI: 10.1016/j.celrep.2021.109765
• Publication Date: 2021-09-30T01:19:05Z
• Authors: Gabriela Leite; Mark Pimentel; Gillian M. Barlow; Christine Chang; Ava Hosseini; Jiajing Wang; Gonzalo Parodi; Rashin Sedighi; Ali Rezaie; Ruchi Mathur
• Keywords: Concomitant; Klebsiella oxytoca; Klebsiella; Escherichia

Gut microbial diversity decreases with aging, but existing studies have used stool samples, which do not represent the entire gut. We analyzed duodenal microbiome in 251 subjects aged 18-35 (n = 32), 36-50 41), 51-65 96), and 66-80 82). Decreased older is associated combinations of chronological age, number concomitant diseases, medications used, also correlated increasing coliform numbers (p < 0.0001). Relative abundance (RA) phylum Proteobacteria increases subjects, increased RA family Enterobacteriaceae genera Escherichia Klebsiella, alterations other taxa decreased diversity. Increased specific are age only (Escherichia, Lactobacillus, Enterococcus), (Klebsiella), or diseases (Clostridium Bilophila). These findings indicate small intestinal changes significantly aging process.