Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury

• DOI: 10.1016/j.celrep.2021.109794
• Publication Date: 2021-10-06T00:39:04Z
• Authors: Hanzhi T. Zhao; Mary Claire Tuohy; Daniel Chow; Mariel G. Kozberg; Sharon H. Kim; Mohammed A. Shaik; Elizabeth M.C. Hi...
• Keywords: Neurovascular bundle; Cortical Spreading Depression

Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbating role in a range of acute brain injuries, including stroke, possibly through their interactions with cortical blood flow. We use simultaneous wide-field imaging neural activity and hemodynamics Thy1-GCaMP6f mice explore the neurovascular dynamics CSDs during following Rose Bengal-mediated photothrombosis. observed all as slow-moving waves GCaMP fluorescence extending far beyond photothrombotic area. Initial accompanied by profound vasoconstriction leave residual oligemia ischemia wake. Later, evoke variable responses, from constriction biphasic vasodilation. However, CSD-evoked is found be more likely rapid, high-amplitude regions stronger ischemia, which, turn, worsens after each repeated CSD. This feedback loop may explain but potentially devastating effects context injury.