Loss and enhancement of layer-selective signals in geniculostriate and corticotectal pathways of adult human amblyopia

Parvocellular cell Superior colliculus Lateral geniculate nucleus Stimulus (psychology) Geniculate Superior Colliculi
DOI: 10.1016/j.celrep.2021.110117 Publication Date: 2021-12-14T16:21:49Z
ABSTRACT
How abnormal visual experiences early in life influence human subcortical pathways is poorly understood. Using high-resolution fMRI and pathway-selective stimuli, we investigate the of amblyopia on response properties effective connectivity adult brain. Compared to normal fellow eyes, stimuli presented amblyopic eye show selectively reduced parvocellular layers lateral geniculate nucleus weaker V1. eye, chromatic stimulus decreases superficial superior colliculus, while robustly increases deep SC with stronger from cortex. Therefore, leads selective alterations geniculostriate corticotectal pathways. These findings provide neural basis for deficits acuity, ocular motor control, attention.
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