Imaging transcriptomics: Convergent cellular, transcriptomic, and molecular neuroimaging signatures in the healthy adult human brain

• DOI: 10.1016/j.celrep.2021.110173
• Publication Date: 2021-12-28T19:07:01Z
• Authors: Daniel Martins; Alessio Giacomel; Steven C.R. Williams; Federico Turkheimer; Ottavia Dipasquale; Mattia Veronese
• Keywords: Human brain; Molecular Imaging

The integration of transcriptomic and neuroimaging data, "imaging transcriptomics," has recently emerged to generate hypotheses about potential biological pathways underlying regional variability in features. However, the validity this approach is yet be examined depth. Here, we sought bridge gap by performing decoding distribution well-known molecular markers spanning different elements biology healthy human brain. Imaging transcriptomics identifies cell that are consistent with known a wide range markers. extent which it can capture patterns gene expression align well neuroinflammatory axis, at least controls without proinflammatory challenge, inconclusive. might constitute an interesting improve our understanding phenotypes.