Brown adipose tissue involution associated with progressive restriction in progenitor competence

• DOI: 10.1016/j.celrep.2022.110575
• Publication Date: 2022-04-13T04:13:46Z
• Authors: Zan Huang; Zengdi Zhang; Zahra Moazzami; Ryan Heck; Ping Hu; Hezkiel Nanda; Kaiqun Ren; Zequn Sun; Alessandro Bartol...; Yan Gao; Dongjun Chung; Weiyun Zhu; Steven Shen; Hai-Bin Ruan
• Keywords: Involution (esoterism); Progenitor

Human brown adipose tissue (BAT) undergoes progressive involution. This involution process is not recapitulated in rodents, and the underlying mechanisms are poorly understood. Here we show that interscapular BAT (iBAT) of rabbits whitens rapidly during early adulthood. The transcriptomic remodeling identity switch mature adipocytes accompanied by loss adipogenic competence progenitors. Single-cell RNA sequencing reveals rabbit human iBAT progenitors highly express FSTL1 gene. When involutes rabbits, adipocyte reduce expression refractory to recruitment. Conversely, constitutively expressed mouse sustain WNT signaling prevent Progenitor incompetence paucity can be induced mice genetic deletion Fstl1 gene or ablation Fstl1+ Our results highlight hierarchy dynamics progenitor compartment implicate functional FSTL1-expressing