BAFFR activates PI3K/AKT signaling in human naive but not in switched memory B cells through direct interactions with B cell antigen receptors

• DOI: 10.1016/j.celrep.2022.111019
• Publication Date: 2022-06-28T20:15:18Z
• Authors: Eirini Sevdali; Violeta Block; Marie Lataretu; Huiying Li; Cristian R. Smulski; Jana-Susann Briem; Yannic Heitz; Beate Fischer; Neftali-Jose Ramirez; Bodo Grimbacher; Hans-Martin Jäck; Reinhard E. Voll; Martin Hölzer; Pascal Schneider; Hermann Eibel
• Keywords: 610; Receptors, Antigen, B-Cell; B-Cell Activating Factor/immunology; B-Cell Activating Factor/metabolism; B-Cell Activation Factor Receptor/immunology; B-Cell Activation Factor Receptor/metabolism; Humans; Memory B Cells/immunology; Memory B Cells/metabolism; Phosphatidylinositol 3-Kinases/immunology; Phosphatidylinositol 3-Kinases/metabolism; Proto-Oncogene Proteins c-akt/immunology; Proto-Oncogene Proteins c-akt/metabolism; Receptors, Antigen, B-Cell/immunology; Receptors, Antigen, B-Cell/metabolism; BAFF; BAFFR; BCR; CP: Immunology; PI3K signaling; human memory B cells; Phosphatidylinositol 3-Kinases; 03 medical and health sciences; Memory B Cells; PI3K SIGNALING; https://purl.org/becyt/ford/3.1; B-Cell Activating Factor; Humans; https://purl.org/becyt/ford/3; ddc:610; PI3K signaling; ddc:610; 0303 health sciences; BAFFR; HUMAN MEMORY B CELLS; BCR; 3. Good health; CP: IMMUNOLOGY; human memory B cells; BAFF; 610 Medizin und Gesundheit; Proto-Oncogene Proteins c-akt; B-Cell Activation Factor Receptor

Binding of BAFF to BAFFR activates in mature B cells PI3K/AKT signaling regulating protein synthesis, metabolic fitness, and survival. In humans, naive memory express the same levels BAFFR, but only seem survive without BAFF. Here, we show that changes expression genes migration, proliferation, growth, BAFF-induced activation requires direct interactions between cell antigen receptor (BCR) components CD79A CD79B is enhanced by AKT coactivator TCL1A. Compared cells, more surface BCRs, which interact better with than IgG or IgA, thus allowing stronger responses As ablation causes death independent signaling, seems act also as an intrinsic factor for