The human blood transcriptome exhibits time-of-day-dependent response to hypoxia: Lessons from the highest city in the world

• DOI: 10.1016/j.celrep.2022.111213
• Publication Date: 2022-08-16T14:48:33Z
• Authors: Gal Manella; Saar Ezagouri; Benoit Champigneulle; Jonathan Gaucher; Monique Mendelson; Emeline Lemarie; Emeric Stauffer; Aurélien Pichon; Connor A. Howe; Stéphane Doutreleau; Marina Golik; Samuel Verges; Gad Asher
• Keywords: Hypoxia

High altitude exposes humans to hypobaric hypoxia, which induces various physiological and molecular changes. Recent studies point toward interaction between circadian rhythms the hypoxic response, yet their human relevance is lacking. Here, we examine effect of different high altitudes in conjunction with time day on whole-blood transcriptome upon an expedition highest city world, La Rinconada, Peru, 5,100 m above sea level. We find that vastly affects blood and, unexpectedly, does not necessarily follow a monotonic response elevation. Importantly, observe daily variance gene expression, especially immune-related genes, largely dependent. Moreover, using digital cytometry approach, estimate relative changes abundance cell types several immune time- Taken together, our data provide evidence for transcriptional hypoxia humans.