Microbiota dysbiosis in primary Sjögren’s syndrome and the ameliorative effect of hydroxychloroquine

• DOI: 10.1016/j.celrep.2022.111352
• Publication Date: 2022-09-13T15:40:01Z
• Authors: Xiaobing Wang; Kun Pang; Jinfeng Wang; Bing Zhang; Zhenwei Liu; Saisai Lu; Xin Xu; Lingxiao Zhu; Zihao Zhou; Miaomiao Niu; Jianxia Gao; Jianmin Li; Fangqing Zhao; Jinyu Wu
• Keywords: Hydroxychloroquine; Dysbiosis

The human microbiome plays an important role in autoimmune diseases. However, there is limited knowledge regarding the microbiota individuals with primary Sjögren's syndrome (pSS). Here, we perform 16S ribosomal RNA gene sequencing of fecal, oral, and vaginal samples from a cohort 133 pSS, 56 non-pSS, 40 healthy control (HC) individuals. Dysbiosis gut, evident patients oral demonstrate greatest extent microbial variation. Multiple key indicator bacteria clinical characteristics are identified across different body sites, implying that dysbiosis has roles pathogenesis pSS. Furthermore, observe pSS-like pre-clinical pSS or non-pSS-related disease, revealing shifts could appear prior to After hydroxychloroquine (HCQ) treatment, partially resolved, although composition remain disordered. These results contribute overall understanding relationship between