Microstimulation of visual area V4 improves visual stimulus detection

• DOI: 10.1016/j.celrep.2022.111392
• Publication Date: 2022-09-20T14:53:07Z
• Authors: Ricardo Kienitz; Kleopatra Kouroupaki; Michael C. Schmid
• Keywords: Neurons; ddc:610; 0303 health sciences; 150; 610; Macaca mulatta; 03 medical and health sciences; Report; 616; Visual Perception; ddc:150; Animals; Photic Stimulation; Vision, Ocular; Visual Cortex

Neuronal activity in visual area V4 is well known to be modulated by selective attention, and there are reports on V4 lesions leading to attentional deficits. However, it remains unclear whether V4 microstimulation can elicit attentional benefits. To test this hypothesis, we performed local microstimulation in area V4 and explored its spatial and time dynamics in two macaque monkeys performing a visual detection task. Microstimulation was delivered via chronically implanted multi-electrode arrays. We found that microstimulation increases average performance by 35% and reduces luminance detection thresholds by -30%. This benefit critically depends on the onset of microstimulation relative to the stimulus, consistent with known dynamics of endogenous attention. These results show that local microstimulation of V4 can improve behavior and highlight the critical role of V4 for attention.