Maternal gut microbiota mediate intergenerational effects of high-fat diet on descendant social behavior
Limosilactobacillus reuteri
Male
0301 basic medicine
570
Medical Sciences
QH301-705.5
610
microbiome
Social and Behavioral Sciences
Diet, High-Fat
Microbiology
Article
social behavior
Mice
03 medical and health sciences
Pregnancy
Virology
Medical Specialties
Medicine and Health Sciences
maternal diet
Animals
Biology (General)
Social Behavior
CP: Microbiology, Gastrointestinal Microbiome, CP: Neuroscience, DOHaD, Limosilactobacillus reuteri, intergenerational, maternal diet, microbiome, neurodevelopment, social behavior, probiotics, Animals, Social Behavior, Dysbiosis, Diet, High-Fat, Pregnancy, Female, Male, Mice
2. Zero hunger
neurodevelopment
DOHaD
CP: Microbiology
Life Sciences
Diet
Gastrointestinal Microbiome
High-Fat
probiotics
Medical Microbiology
CP: Neuroscience
intergenerational
Dysbiosis
Female
DOI:
10.1016/j.celrep.2022.111461
Publication Date:
2022-10-11T15:11:37Z
AUTHORS (8)
ABSTRACT
Dysbiosis of the maternal gut microbiome during pregnancy is associated with adverse neurodevelopmental outcomes. We previously showed that maternal high-fat diet (MHFD) in mice induces gut dysbiosis, social dysfunction, and underlying synaptic plasticity deficits in male offspring (F1). Here, we reason that, if HFD-mediated changes in maternal gut microbiota drive offspring social deficits, then MHFD-induced dysbiosis in F1 female MHFD offspring would likewise impair F2 social behavior. Metataxonomic sequencing reveals reduced microbial richness among female F1 MHFD offspring. Despite recovery of microbial richness among MHFD-descendant F2 mice, they display social dysfunction. Post-weaning Limosilactobacillus reuteri treatment increases the abundance of short-chain fatty acid-producing taxa and rescues MHFD-descendant F2 social deficits. L. reuteri exerts a sexually dimorphic impact on gut microbiota configuration, increasing discriminant taxa between female cohorts. Collectively, these results show multigenerational impacts of HFD-induced dysbiosis in the maternal lineage and highlight the potential of maternal microbiome-targeted interventions for neurodevelopmental disorders.
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