Periostin activates distinct modules of inflammation and itching downstream of the type 2 inflammation pathway

• DOI: 10.1016/j.celrep.2022.111933
• Publication Date: 2023-01-06T15:38:10Z
• Authors: Satoshi Nunomura; Daisuke Uta; Isao Kitajima; Yasuhiro Nanri; Kosuke Matsuda; Naoko Ejiri; Midori Kitajima; Hitoshi Ikemitsu; Misaki Koga; Sayaka Yamamoto; Yuko Honda; Hironobu Takedomi; Tsugunobu Andoh; Simon J. Conway; Kenji Izuhara
• Keywords: Itching; Periostin; Allergic Inflammation

Atopic dermatitis (AD) is a chronic relapsing skin disease accompanied by recurrent itching. Although type 2 inflammation dominant in allergic inflammation, it not fully understood how non-type co-exists with or causes We have recently established the FADS mouse, mouse model of AD. In mice, either genetic disruption pharmacological inhibition periostin, downstream molecule inhibits NF-κB activation keratinocytes, leading to downregulating eczema, epidermal hyperplasia, and infiltration neutrophils, without regulating enhanced inflammation. Moreover, periostin blocks spontaneous firing superficial dorsal horn neurons followed decrease scratching behaviors due Taken together, links NF-κB-mediated promotes itching suggesting that promising therapeutic target for