KIR+CD8+ and NKG2A+CD8+ T cells are distinct innate-like populations in humans

• DOI: 10.1016/j.celrep.2023.112236
• Publication Date: 2023-03-09T20:12:37Z
• Authors: Seong Jin Choi; June-Young Koh; Min-Seok Rha; In-Ho Seo; Hoyoung Lee; Seongju Jeong; Su-Hyung Park; Eui-Cheol Shin
• Keywords: Receptors, KIR; QH301-705.5; Humans; Receptors, Natural Killer Cell; CP: Immunology; Biology (General); CD8-Positive T-Lymphocytes; Receptors, Immunologic; NK Cell Lectin-Like Receptor Subfamily C

Subsets of the human CD8+ T cell population express inhibitory NK receptors, such as killer immunoglobulin-like receptors (KIRs) and NKG2A. In present study, we examine phenotypic functional characteristics KIR+CD8+ cells NKG2A+CD8+ cells. KIRs NKG2A tend to be expressed by in a mutually exclusive manner. addition, TCR clonotypes barely overlap with those cells, are more terminally differentiated replicative senescent than Among cytokine IL12Rβ1, IL12Rβ2, IL18Rβ highly whereas IL2Rβ is IL-12/IL-18-induced production IFN-γ prominent IL-15-induced NK-like cytotoxicity These findings suggest that distinct innate-like populations different responsiveness.