UBL7 enhances antiviral innate immunity by promoting Lys27-linked polyubiquitination of MAVS

• DOI: 10.1016/j.celrep.2023.112272
• Publication Date: 2023-03-20T11:10:29Z
• Authors: Wei Jiang; Xinyu Li; Henan Xu; Xiuling Gu; Shan Li; Li Zhu; Jiao Lu; Xuefeng Duan; Wei Li; Min Fang
• Keywords: Proinflammatory cytokine; RIG-I; Interferon type I

RNA virus infection usually triggers a range of host immune responses, including the induction proinflammatory cytokines, interferons, and interferon-stimulated genes (ISGs). Here, we report that UBL7, ubiquitin-like protein, is upregulated during induced by type I interferon as an ISG. UBL7-deficient mice exhibit increased susceptibility to viral due attenuated antiviral innate immunity. UBL7 enhances response promoting K27-linked polyubiquitination MAVS. interacts with TRIM21, E3 ubiquitin ligase MAVS, promotes combination TRIM21 MAVS in dose-dependent manner, facilitating recruiting TBK1 enhance IFN signaling pathway. Moreover, has broad-spectrum function immunomodulatory adaptor protein. Therefore, positively regulates positive feedback amplify response.