Vaccination provides superior in vivo recall capacity of SARS-CoV-2-specific memory CD8 T cells

• DOI: 10.1016/j.celrep.2023.112395
• Publication Date: 2023-04-04T07:35:50Z
• Authors: Inga Kavazović; Christoforos Dimi...; Dora Gašparini; Mari Rončević Fil...; Igor Barković; Jan Koster; Niels A. Lemmermann; Marina Babić; Đurđica Cekinović...; Felix M. Wensveen
• Keywords: Ex vivo

Memory CD8 T cells play an important role in the protection against breakthrough infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Whether route of antigen exposure impacts these at a functional level is incompletely characterized. Here, we compare memory cell response common SARS-CoV-2 epitope after vaccination, infection, or both. demonstrate comparable capacity when restimulated directly ex vivo, independent antigenic history. However, analysis receptor usage shows that vaccination results narrower scope than infection alone combination vaccination. Importantly, vivo recall model, from infected individuals show equal proliferation but secrete less tumor necrosis factor (TNF) compared those vaccinated people. This difference negated have also been vaccinated. Our findings shed more light on differences susceptibility to re-infection different routes exposure.