Potent Omicron-neutralizing antibodies isolated from a patient vaccinated 6 months before Omicron emergence

• DOI: 10.1016/j.celrep.2023.112421
• Publication Date: 2023-04-10T07:13:19Z
• Authors: Kathryn M. Hastie; Xiaoying Yu; Fernanda Ana-Sosa...; Dawid S. Zyla; Stephanie S. Harkins; Chitra Hariharan; Hal Wasserman; Michelle A. Zando...; Robyn Miller; Erin Maule; Kenneth Kim; Kristen M. Valentine; Sujan Shresta; Erica Ollmann Sap...
• Keywords: 0301 basic medicine; QH301-705.5; SARS-CoV-2; CP: Microbiology; COVID-19; CP: Immunology; Antibodies, Viral; Antibodies, Neutralizing; Article; 3. Good health; Mice; 03 medical and health sciences; Animals; Biology (General); Broadly Neutralizing Antibodies

Therapeutic antibodies are an important tool in the arsenal against coronavirus infection. However, most developed early pandemic have lost or all efficacy newly emergent strains of severe acute respiratory syndrome 2 (SARS-CoV-2), particularly those Omicron lineage. Here, we report identification a panel vaccinee-derived that broad-spectrum neutralization activity. Structural and biochemical characterization three broadest-spectrum reveal complementary footprints differing requirements for avidity to overcome variant-associated mutations their binding footprints. In K18 mouse model infection, these exhibit protective BA.1 BA.2 This study highlights resilience vulnerabilities SARS-CoV-2 provides road maps further development therapeutics.