Modeling human ectopic pregnancies with trophoblast and vascular organoids
Trophoblast
Vasculogenesis
Organoid
Ectopic expression
Progenitor
DOI:
10.1016/j.celrep.2023.112546
Publication Date:
2023-05-23T11:24:00Z
AUTHORS (18)
ABSTRACT
Ruptured ectopic pregnancy (REP), a complication caused by aberrant implantation, deep invasion, and overgrowth of embryos in fallopian tubes, could lead to rupture tubes accounts for 4%-10% pregnancy-related deaths. The lack phenotypes rodents hampers our understanding its pathological mechanisms. Here, we employed cell culture organoid models investigate the crosstalk between human trophoblast development intravillous vascularization REP condition. Compared with abortive (AEP), size placental villi depth invasion are correlated extent vascularization. We identified key pro-angiogenic factor secreted trophoblasts, WNT2B, that promotes villous vasculogenesis, angiogenesis, vascular network expansion Our results reveal important role WNT-mediated angiogenesis an co-culture model investigating intricate communications trophoblasts endothelial/endothelial progenitor cells.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (64)
CITATIONS (6)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....