The human placenta exhibits a unique transcriptomic void

• DOI: 10.1016/j.celrep.2023.112800
• Publication Date: 2023-07-14T05:08:04Z
• Authors: Sungsam Gong; Francesca Gaccioli; Irving L.M.H. Aye; Giulia Avellino; Emma Cook; Andrew R.J. Lawson; Luke M.R. Harvey; Gordon C.S. Smith; D. Stephen Charno...
• Keywords: Void (composites); Human placenta

The human placenta exhibits a unique genomic architecture with an unexpectedly high mutation burden and many uniquely expressed genes. aim of this study is to identify transcripts that are absent or depleted in the placenta. Here, we show 40 46 other organs have no selectively that, remaining six, liver has largest number, 26. In contrast, term 762 transcripts. Gene Ontology analysis set highlighted multiple pathways reflecting known elements placental physiology. For example, associated neuronal function set-as expected given lack innervation. However, demonstrated overrepresentation genes involved mitochondrial (p = 5.8 × 10