Transcription factor TCF-1 regulates the functions, but not the development, of lymphoid tissue inducer subsets in different tissues

• DOI: 10.1016/j.celrep.2023.112924
• Publication Date: 2023-08-03T18:54:23Z
• Authors: Mingzhu Zheng; Chen Yao; Gang Ren; Kairui Mao; Hyunwoo Chung; Xi Chen; Gangqing Hu; Lei Wang; Xuemei Luan; Difeng Fang; Dan Li; Chao Zhong; Xiaoxiao Lu; Nikki Cannon; Mingxu Zhang; Avinash Bhandoola; Keji Zhao; John J. O’Shea; Jinfang Zhu
• Keywords: Innate lymphoid cell; Inducer; Organogenesis

Lymphoid tissue inducer (LTi) cells, a subset of innate lymphoid cells (ILCs), play an essential role in the formation secondary tissues. However, regulation development and functions this ILC is still elusive. In study, we report that transcription factor T cell 1 (TCF-1), just as GATA3, indispensable for non-LTi subsets. While LTi are present TCF-1-deficient mice, organogenesis Peyer's patches (PPs), but not lymph nodes, impaired these mice. from different tissues have distinct gene expression patterns, TCF-1 regulates lymphotoxin specifically PP cells. Mechanistically, may directly and/or indirectly regulate Lta, including through promoting GATA3. Thus, TCF-1-GATA3 axis, which plays important during development, also critically tissue-specific