Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice

• DOI: 10.1016/j.celrep.2023.112946
• Publication Date: 2023-08-08T03:20:22Z
• Authors: Natasha M. Kafai; Hana Janova; Matthew D. Cain; Yael Alippe; Stefanie Muraro; Alan Sariol; Michelle Elam-Noll; Robyn S. Klein; Michael S. Diamond
• Keywords: Pathogenesis

Venezuelan equine encephalitis virus (VEEV) is an encephalitic alphavirus responsible for epidemics of neurological disease across the Americas. Low-density lipoprotein receptor class A domain-containing 3 (LDLRAD3) a recently reported entry VEEV. Here, using wild-type and Ldlrad3-deficient mice, we define critical role LDLRAD3 in controlling steps VEEV infection, pathogenesis, neurotropism. Our analysis shows that required efficient infection pathogenesis prior to after central nervous system invasion. mice survive intranasal intracranial inoculation show reduced neurons different brain regions. As determinant brain, receptor-targeted therapies may hold promise as countermeasures.