Organization of Purkinje cell development by neuronal MEGF11 in cerebellar granule cells

• DOI: 10.1016/j.celrep.2023.113137
• Publication Date: 2023-09-13T19:50:32Z
• Authors: Soyoung Jun; Muwoong Kim; Heeyoun Park; Eunmi Hwang; Yukio Yamamoto; Keiko Tanaka-Yama...
• Keywords: Granule (geology); Granule cell

As cerebellar granule cells (GCs) coordinate the formation of regular networks during postnatal development, molecules in GCs are expected to be involved. Here, we test effects knockdown (KD) multiple epidermal growth factor-like domains protein 11 (MEGF11), which is a homolog proteins mediating astrocytic phagocytosis but substantially increased at later developmental stages on development. MEGF11-KD developing mice results abnormal structures, including extensively ectopic Purkinje cell (PC) somas, and impaired motor functions. also causes abnormally asynchronous synaptic release from GC axons, parallel fibers, before appearance structures. Interestingly, blockade this restores most Thus, apart phagocytic functions its related homologs astrocytes, MEGF11 promotes proper PC development network by regulating immature transmission.