Typhoid toxin hijacks Wnt5a to establish host senescence and Salmonella infection

• DOI: 10.1016/j.celrep.2023.113181
• Publication Date: 2023-10-04T05:13:51Z
• Authors: Mohamed ElGhazaly; Mark O. Collins; Angela E.M. Ibler; Daniel Humphreys
• Keywords: Senescence; Salmonella enterica

Damage to our genome causes acute senescence in mammalian cells, which undergo growth arrest and release a senescence-associated secretory phenotype (SASP) that propagates the stress response bystander cells. Thus, is powerful tumor suppressor. Salmonella enterica hijacks through its typhoid toxin, usurps unidentified factors secretome of senescent cells mediate intracellular infections. Here, transcriptomics toxin-induced (TxSCs) proteomics their identify as Wnt5a, INHBA, GDF15. Wnt5a establishes positive feedback loop, driving INHBA GDF15 expression. In fibroblasts, autocrine TxSCs paracrine naive synergizes with increase invasion. Intestinal apoptosis without required for establishing intestinal TxSCs. The study reveals how an innate defense against cancer co-opted by bacterial pathogen cause widespread damage