Reward learning improves social signal processing in autism model mice

• DOI: 10.1016/j.celrep.2023.113228
• Publication Date: 2023-10-09T10:15:46Z
• Authors: Joowon Kim; Min Whan Jung; Doyun Lee
• Keywords: Knockout mouse; Reward system; Association (psychology)

Social and reward signal processing their association are critical elements of social motivation. Despite the use learning to improve interactions patients with autism spectrum disorder (ASD), underlying neural mechanisms unknown. Here, we found different yet conjunct neuronal representations signals in mouse medial prefrontal cortex (mPFC). We also that is selectively disrupted, whereas intact mPFC Shank2-knockout mice, a model ASD. Furthermore, not only allows mice associate stimuli availability, but it rescues impaired processing. These findings provide insights into basis for therapeutic