Toll-like receptor 4 and CD11b expressed on microglia coordinate eradication of Candida albicans cerebral mycosis
Medical Sciences
Amyloid beta-Peptides
CD11b Antigen
QH301-705.5
Medical Immunology
610
Diseases
CP: Immunology
Article
3. Good health
Fungal Proteins
Toll-Like Receptor 4
Mice
Immune System Diseases
Mycoses
Alzheimer Disease
Allergy and Immunology
CP: Neuroscience
616
Candida albicans
Medical Specialties
Medicine and Health Sciences
Animals
Microglia
Biology (General)
DOI:
10.1016/j.celrep.2023.113240
Publication Date:
2023-10-17T09:29:41Z
AUTHORS (20)
ABSTRACT
The fungal pathogen Candida albicans is linked to chronic brain diseases such as Alzheimer's disease (AD), but the molecular basis of anti-Candida immunity remains unknown. We show that C. enters mouse from blood and induces two neuroimmune sensing mechanisms involving secreted aspartic proteinases (Saps) candidalysin. Saps disrupt tight junction proteins blood-brain barrier (BBB) permit invasion. also hydrolyze amyloid precursor protein (APP) into β (Aβ)-like peptides bind Toll-like receptor 4 (TLR4) promote killing in vitro while candidalysin engages integrin CD11b (Mac-1) on microglia. Recognition Aβ-like promotes clearance brain, disruption recognition through markedly prolongs cerebral mycosis. Thus, cleared innate immune Saps, Aβ, candidalysin, CD11b.
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CITATIONS (23)
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