A global survey of host, aquatic, and soil microbiomes reveals shared abundance and genomic features between bacterial and fungal generalists

• DOI: 10.1016/j.celrep.2024.114046
• Publication Date: 2024-04-05T23:45:44Z
• Authors: Daniel Loos; Ailton Pereira da...; Bas E. Dutilh; Amelia E. Barber; Gianni Panagiotou
• Keywords: 0301 basic medicine; 2. Zero hunger; Bacteria; QH301-705.5; Microbiota; General Biochemistry,Genetics and Molecular Biology; CP: Microbiology; Fungi; microbiome; Biodiversity; Genomics; 15. Life on land; microbial ecology; bacterial-fungal interactions; 03 medical and health sciences; generalism; 13. Climate action; Humans; Biology (General); environmental adaptation; Soil Microbiology; Phylogeny

AbstractEnvironmental change coupled with alteration in human lifestyles are profoundly impact-ing the microbial communities that play critical roles in the health of the Earth and its inhabitants. To identify bacteria and fungi that are resistant and susceptible to habitat changes respectively, we retrieved paired 16S and ITS rRNA amplicon sequence data from 1,580 host, soil, and aquatic samples and explored the ecological patterns of the thousands of detected bacterial and fungal genera. Through this large-scale analysis, we identified 48 bacterial and 4 fungal genera that were prevalent and abundant across the three biomes, demonstrating their fitness in diverse environmental conditions. The presence of generalists significantly contributed to the alpha diversity of their respective kingdom. Their distri-bution across samples explained a large percentage of the variation in the cross-kingdom community structure. We also found that the genomes of these generalists were larger and encoded more secondary metabolism and antimicrobial resistance genes, illuminating how they can dominate diverse microbial communities. Conversely, 30 bacterial and 19 fungal genera were only found in a single habitat, suggesting they cannot readily adapt to different and changing environments. These findings can contribute to our understanding of microbial niche breadth and its consequences for global diversity loss.