Nuclear HMGB1 is critical for CD8 T cell IFN-γ production and anti-tumor immunity

• DOI: 10.1016/j.celrep.2024.114591
• Publication Date: 2024-08-08T07:21:02Z
• Authors: Zhiguang Xu; Weiying Ma; Ji Wang; Haofan Chen; Hui Li; Zhinan Yin; Jianlei Hao; Kebing Chen
• Keywords: HMGB1

HMGB1 (high-mobility group box-1) has been extensively studied as a damage-associated molecular pattern, with secreted cytokine function. However, its regulation on T cells, especially the function in nucleus, not elucidated. Here, we use conditional knockout (HMGB1-f/f; CD2-cre) mice and find that potentiates proliferation interferon gamma (IFN-γ) expression of CD8 cells rather than CD4 cells. Notably, nuclear, but secreted, supports IFN-γ via directly regulating activity Eomes, transcription factor for IFN-γ. Functional study shows promotes anti-tumor ability vitro vivo. Finally, tumor environmental interleukin-7 production fatty acid oxidation Overall, identify role nuclear cell differentiation demonstrate it plays an important programs