The low-dose CHK1 inhibitor prexasertib triggers VDAC1 dephosphorylation to activate mtDNA-STING signaling and synergize immunotherapy

• DOI: 10.1016/j.celrep.2025.115605
• Publication Date: 2025-04-17T18:35:39Z
• Authors: Yu Fu; Xiaoyan Kang; Wenting Li; Zanhong Wang; Wanwan Luo; Bin Yang; Yaoyuan Cui; Funian Lu; Tianyu Qin; Xingyuan Hu; Jingjing Yin; Xi Li; Junpeng Fan; Beibei Wang; Gang Chen; Rourou Xiao; Zhiqiang Han; Ensong Guo; Xu Qin
• Keywords: Dephosphorylation; Sting