ACE2 Expression in Pancreas May Cause Pancreatic Damage After SARS-CoV-2 Infection

• DOI: 10.1016/j.cgh.2020.04.040
• Publication Date: 2020-04-23T00:37:57Z
• Authors: Furong Liu; Xin Long; Bixiang Zhang; Wanguang Zhang; Xiaoping Chen; Zhanguo Zhang
• Keywords: Adult; Male; Hepatology; Adolescent; SARS-CoV-2; Gene Expression Profiling; Pneumonia, Viral; Gastroenterology; COVID-19; Pancreatic Diseases; Middle Aged; Peptidyl-Dipeptidase A; Article; 3. Good health; Betacoronavirus; Young Adult; Humans; Receptors, Virus; Female; Angiotensin-Converting Enzyme 2; Coronavirus Infections; Pancreas; Pandemics; Aged

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus that causes coronavirus disease 2019 (COVID-19) in human beings, has caused a serious public health issue.1 Attention to pancreatic injury is lacking, which may impact patients' prognosis. In this study, we explored the expression and distribution of angiotensin-converting enzyme 2 (ACE2), the receptor of SARS-CoV-2, in the pancreas. Combined with clinical data, we showed that pancreatic injury can occur in some COVID-19 patients.