PFAS levels and exposure determinants in sensitive population groups

• DOI: 10.1016/j.chemosphere.2022.137530
• Publication Date: 2022-12-09T19:28:55Z
• Authors: L. Fábelová; A. Beneito; M. Casas; A. Colles; L. Dalsager; E. Den Hond; C. Dereumeaux; K. Ferguson; L. Gilles; E. Govarts; A. Irizar; M.J. Lopez Espinosa; P. Montazeri; B. Morrens; H. Patayová; K. Rausová; D. Richterová; L. Rodriguez Martin; L. Santa-Marina; T. Schettgen; G. Schoeters; L.S. Haug; M. Uhl; G.D. Villanger; M. Vrijheid; C. Zaros; Ľ Palkovičová Mur...
• Keywords: info:eu-repo/classification/ddc/333.7; Maternal blood; Vulnerable Populations; 01 natural sciences; Pregnancy; per-and polyfluoroalkyl substances; Animals; Humans; Food consumption; Biology; Determinants; 0105 earth and related environmental sciences; per- and polyfluoroalkyl substances; Fluorocarbons; infermeria; 333.7; Cord blood; Diet; Chemistry; Parity; Alkanesulfonic Acids; 13. Climate action; Per- and polyfluoroalkyl substances; Female; Environmental Pollutants; F ood consumption

Per- and polyfluoroalkyl substances (PFAS) are persistent organic pollutants. The first exposure to PFAS occurs in utero, after birth it continues via breast milk, food intake, environment, consumer products that contain these chemicals. Our aim was identify determinants of concentrations sensitive population subgroups– pregnant women newborns. Nine European cohorts provided data on (INMA-Gipuzkoa, Sabadell, Valencia, ELFE MoBa; total N = 5897) or newborns (3xG study, FLEHS 2, 3 PRENATAL; 940). PFOS, PFOA, PFHxS PFNA were measured maternal cord blood, depending the cohort (FLEHS 2 only PFOS PFOA). analysed according characteristics (age, BMI, parity, previous breastfeeding, smoking, consumption during pregnancy) parental educational level. association between potential evaluated using multiple linear regression models. We observed significant variations among cohorts. Higher associated with higher age, primipara birth, level, both for blood blood. fish seafood, meat, offal eggs. In daily meat consumption. Daily milk dairy lower both, High detection rates four most abundant demonstrate ubiquitous populations, which is concern. This study identified several newborns, including dietary factors, findings can be used proposing measures reduce exposure, particularly from sources.