Crafty mimicry grants nuclear pore entry to HIV

• DOI: 10.1016/j.chom.2024.03.004
• Publication Date: 2024-04-10T14:39:04Z
• Authors: Keesiang Lim; Masaharu Hazawa; Richard W. Wong
• Keywords: Nuclear pore

The size of the nuclear pore should, in principle, prevent HIV-1 entry. However, HIV-1 capsid is able to gain nuclear pore entry. In a recent issue of Nature, Fu et al. and Dickson et al. demonstrate that the HIV-1 capsid mimics the nuclear transport protein karyopherins to access host nuclei.