Low-Density Neutrophils and Neutrophil Extracellular Traps (NETs) Are New Inflammatory Players in Heart Failure

• DOI: 10.1016/j.cjca.2024.03.018
• Publication Date: 2024-03-28T17:52:40Z
• Authors: Benjamin L. Dumont; Paul-Eduard Neagoe; Elcha Charles; Louis Villeneuve; Sandro Ninni; Jean-Claude Tardif; Agnès Räkel; Michel White; Martin G. Sirois
• Keywords: Neutrophil Extracellular Traps

Heart failure with reduced (HFrEF) or preserved ejection fraction (HFpEF) is characterized by low-grade chronic inflammation. Circulating neutrophils regroup 2 subtypes termed high- and low-density (HDNs LDNs). LDNs represent less than 2% of total neutrophil under physiological conditions, but their counts increase in multiple pathologies, releasing more inflammatory cytokines extracellular traps (NETs). The aims this study were to assess the differential count role HDNs, LDNs, NETs-related activities patients heart (HF).