MRI appearance of BRCA-associated prostate cancer
Male
03 medical and health sciences
0302 clinical medicine
Mutation
Humans
Prostatic Neoplasms
Prognosis
Magnetic Resonance Imaging
3. Good health
DOI:
10.1016/j.clinimag.2022.02.007
Publication Date:
2022-02-19T02:03:41Z
AUTHORS (5)
ABSTRACT
Despite advances in diagnosis and treatment, prostate cancer remains the second leading cause of cancer related mortality in men. Prognosis is variable and dependent on several clinical and genetic factors, including BRCA gene mutations. Recent clinical studies have reported that BRCA-associated prostate cancer is a more aggressive subtype with a higher probability of nodal involvement and distant metastases at the time of diagnosis, but radiological findings have not been described. Accurate recognition of those tumors could help guide clinical management and prompt testing and counseling for BRCA mutations. We have recently encountered four patients with BRCA-associated prostate cancer who underwent multiparametric MRI. The MRI appearances of these tumors, which were generally locally advanced and aggressive in appearance, are presented to facilitate recognition of BRCA-associated prostate cancer and guide potential genetic testing and counseling.
SUPPLEMENTAL MATERIAL
Coming soon ....
REFERENCES (13)
CITATIONS (2)
EXTERNAL LINKS
PlumX Metrics
RECOMMENDATIONS
FAIR ASSESSMENT
Coming soon ....
JUPYTER LAB
Coming soon ....