Secondary somatosensory cortex evoked responses and 6-year neurodevelopmental outcome in extremely preterm children

• DOI: 10.1016/j.clinph.2021.04.005
• Publication Date: 2021-04-28T17:40:01Z
• Authors: Piia Lönnberg; Elina Pihko; Leena Lauronen; Jussi Nurminen; Sture Andersson; Marjo Metsäranta; Aulikki Lano; Päivi Nevalainen
• Keywords: Somatosensory evoked potential

We assessed in extremely preterm born (EPB) children whether secondary somatosensory cortex (SII) responses recorded with magnetoencephalography (MEG) at term-equivalent age (TEA) correlate neurodevelopmental outcome 6 years. Secondly, we SII differ between 6-year-old EPB and term-born (TB) children.39 underwent MEG tactile stimulation TEA. At years, 32 26 TB including a sensorimotor task requiring attention motor inhibition. to were modeled equivalent current dipoles. Neurological outcome, competence, general cognitive ability prospectively evaluated years.Unilaterally absent response TEA was associated abnormal competence (p = 0.03). bilaterally detectable most (88%) (92%) (group comparison, p 0.69). Motor inhibition decreased peak latencies children, but lacked this effect 0.02).Unilateral absence of an predicted poorer children.Neurophysiological methods may provide new means for prognostication children.