Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study

• DOI: 10.1016/j.clnu.2021.05.034
• Publication Date: 2021-06-09T07:49:09Z
• Authors: Jong Bin Bae; Ji Won Han; Junghan Song; Kyunghoon Lee; Tae Hui Kim; Kyung Phil Kwak; Bong Jo Kim; Shin Gyeom Kim; Jeong Lan Kim; Seok Woo Moon; Joon Hyuk Park; Seung-Ho Ryu; Jong Chul Youn; Dong Young Lee; Dong Woo Lee; Seok Bum Lee; Jung Jae Lee; Jin Hyeong Jhoo; Ki Woong Kim
• Keywords: Hyperhomocysteinemia

Hyperhomocysteinemia has been repeatedly found to increase the risk of dementia. However, effects hypohomocysteinemia on dementia have barely investigated. If hypohomocysteinemia, like hyperhomocysteinemia, increases dementia, misuse or overuse homocysteine-lowing agents such as vitamin supplements may dementia.To investigate whether could and Alzheimer's disease (AD) in a large population-based cohort older adults.This prospective study followed 2655 randomly sampled, community-dwelling, non-demented individuals aged 60 years from 2010 2018. We measured baseline serum total homocysteine (tHcy) levels examined effect tHcy risks AD using Cox proportional hazards models.During follow-up period (mean = 5.4 years, SD 0.9), developed 85 64 participants, respectively. Not only participants with high (≥10.6 μmol/L) but also those low (≤8.9 were 4-5 times more likely develop compared between 9.0 10.5 μmol/L. With concentration, use decreased, 41.2% taking supplements.Not hyperhomocysteinemia considerably increased adults. The that results should be acknowledged homocysteine-lowering health policies tailored consider are associated hypohomocysteinemia.