Hypohomocysteinemia may increases the risk of dementia and Alzheimer's disease: A nationwide population-based prospective cohort study
Hyperhomocysteinemia
DOI:
10.1016/j.clnu.2021.05.034
Publication Date:
2021-06-09T07:49:09Z
AUTHORS (19)
ABSTRACT
Hyperhomocysteinemia has been repeatedly found to increase the risk of dementia. However, effects hypohomocysteinemia on dementia have barely investigated. If hypohomocysteinemia, like hyperhomocysteinemia, increases dementia, misuse or overuse homocysteine-lowing agents such as vitamin supplements may dementia.To investigate whether could and Alzheimer's disease (AD) in a large population-based cohort older adults.This prospective study followed 2655 randomly sampled, community-dwelling, non-demented individuals aged 60 years from 2010 2018. We measured baseline serum total homocysteine (tHcy) levels examined effect tHcy risks AD using Cox proportional hazards models.During follow-up period (mean = 5.4 years, SD 0.9), developed 85 64 participants, respectively. Not only participants with high (≥10.6 μmol/L) but also those low (≤8.9 were 4-5 times more likely develop compared between 9.0 10.5 μmol/L. With concentration, use decreased, 41.2% taking supplements.Not hyperhomocysteinemia considerably increased adults. The that results should be acknowledged homocysteine-lowering health policies tailored consider are associated hypohomocysteinemia.
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