A pattern emerges in chromatin aging: AP-1 steals the show

• DOI: 10.1016/j.cmet.2024.07.015
• Publication Date: 2024-08-06T15:08:47Z
• Authors: Cian J. Lynch; Laia Richart; Manuel Serrano
• Keywords: Transcription

During aging, transcriptional programs of cell identity are partially eroded, reducing cellular fitness and resilience. Patrick et al.1 unveil a general mechanism for this process that consists of the progressive loss of transcription factor AP-1 from cell identity enhancers and its relocation by competition to stress-response elements.