A pattern emerges in chromatin aging: AP-1 steals the show

Transcription
DOI: 10.1016/j.cmet.2024.07.015 Publication Date: 2024-08-06T15:08:47Z
ABSTRACT
During aging, transcriptional programs of cell identity are partially eroded, reducing cellular fitness and resilience. Patrick et al.1 unveil a general mechanism for this process that consists of the progressive loss of transcription factor AP-1 from cell identity enhancers and its relocation by competition to stress-response elements.
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