Impact of testing on Clostridioides difficile infection in hospitals across Europe: a mathematical model

• DOI: 10.1016/j.cmi.2023.02.004
• Publication Date: 2023-02-10T02:24:28Z
• Authors: Emily Agnew; Kerrie A. Davies; Virginie F. Viprey; Stephanie Evans; Georgina L. Davis; Russell Hope; Mark H. Wilcox; Sebastian M. Wing...; Julie V. Robotham
• Keywords: Clostridioides

The prevalence of Clostridioides difficile infection (CDI) has been shown to vary markedly between European countries, both in hospitals and the community. Determining true proven challenging. Without systematic testing hospitals, unchecked transmission CDI can lead large outbreaks more susceptible cohorts. We investigate success surveillance control measures across Europe, by examining dynamics disease spread from community into a hospital setting. focus on national differences, such as variability sampling, communities antimicrobial usage.We developed stochastic, compartmental, dynamic mathematical model parameterized using sampling rate data COMBACTE-CDI, multicountry study which all diarrhoeal stool samples (N = 3163) laboratories were tested for CDI, usage incidence cases sourced Centre Disease Prevention Control.The framework estimates among patients countries explores how differences impact dynamics, transmission, relative within illustrates mechanisms influencing these namely, rates, CDI.Differential costs practicalities scaling up mean every country needs consider balancing against treatment care with CDI.