Imported severe West Nile virus neuro-invasive disease treated by remdesivir in a patient with anti-CD20 therapy for multiple sclerosis: A case report

• DOI: 10.1016/j.cmicom.2024.105034
• Publication Date: 2024-09-27T21:47:36Z
• Authors: Ehtesham Shamsher; Jonathan Dash; Jacques Serratrice; Matteo Coen; Aurélie Zacharias...; Florian Laubscher; Manuel Schibler; Marjolaine Uginet; Pauline Vetter
• Keywords: Multiple sclerosis; Remdesivir; Ocrelizumab; Infectious and parasitic diseases; RC109-216; Public aspects of medicine; RA1-1270; West Nile virus; Immunosuppression

West Nile virus (WNV) infection can lead to severe disease, especially in immunocompromised individuals. We report a case of neuroinvasive WNV in a patient receiving ocrelizumab for multiple sclerosis, who recovered after remdesivir and immunoglobulin treatment. This case highlights the diagnostic and therapeutic challenges regarding neuroinvasive WNV infection in immunocompromised patients.