Multi-modal discriminative dictionary learning for Alzheimer's disease and mild cognitive impairment

• DOI: 10.1016/j.cmpb.2017.07.003
• Publication Date: 2017-07-18T23:31:43Z
• Authors: Qing Li; Xia Wu; Lele Xu; Kewei Chen; Li Yao; Rui Li
• Keywords: SPARSE REPRESENTATION; AMYLOID LOAD; Technology; Biomedical; Theory & Methods; 150; 610; CONNECTIVITY NETWORKS; Neuroimaging; DIAGNOSIS; MCI PATIENTS; CLASSIFICATION; 03 medical and health sciences; POSITRON-EMISSION-TOMOGRAPHY; Engineering; 0302 clinical medicine; CEREBROSPINAL-FLUID; Alzheimer Disease; Humans; Interdisciplinary Applications; Cognitive Dysfunction; FDG-PET; Brain disorders; Science & Technology; Brain; Magnetic Resonance Imaging; 3. Good health; Positron-Emission Tomography; Alzheimer's disease (AD); Computer Science; Discriminative dictionary; MR-IMAGES; Supervised Machine Learning; Multimodal neuroimaging data; Life Sciences & Biomedicine; Mild cognitive impairment (MCI); Medical Informatics; Algorithms

The differentiation of mild cognitive impairment (MCI), which is the prodromal stage of Alzheimer's disease (AD), from normal control (NC) is important as the recent research emphasis on early pre-clinical stage for possible disease abnormality identification, intervention and even possible prevention.The current study puts forward a multi-modal supervised within-class-similarity discriminative dictionary learning algorithm (SCDDL) we introduced previously for distinguishing MCI from NC. The proposed new algorithm was based on weighted combination and named as multi-modality SCDDL (mSCDDL). Structural magnetic resonance imaging (sMRI), fluorodeoxyglucose (FDG) positron emission tomography (PET) and florbetapir PET data of 113 AD patients, 110 MCI patients and 117 NC subjects from the Alzheimer's disease Neuroimaging Initiative database were adopted for classification between MCI and NC, as well as between AD and NC.Adopting mSCDDL, the classification accuracy achieved 98.5% for AD vs. NC and 82.8% for MCI vs. NC, which were superior to or comparable with the results of some other state-of-the-art approaches as reported in recent multi-modality publications.The mSCDDL procedure was a promising tool in assisting early diseases diagnosis using neuroimaging data.