Bi-functionalization of titanium with a mixture of peptides for improving its osteogenic and antibacterial activity

• DOI: 10.1016/j.colcom.2022.100673
• Publication Date: 2022-10-19T06:27:41Z
• Authors: Qiang Tang; Weina Wang; Xiaojing Zhang; Xingtang Fang; Chunlei Zhang; Zhaojing Zhu; Yanhua Hou; Min Lai
• Keywords: Surface Modification

Poor osteointegration and implant infection are two of the main causes that hinder success clinical implants. In order to enhance osteogenesis antibacterial activity titanium, BFP-1 GL13K peptides were immobilized on surface micro/nanostructured titanium using dopamine as a coupling mechanism. Successful construction surfaces was demonstrated by several material characterization methods including scanning electron microscopy (SEM), atomic force microscope (AFM), water contact angle measurements X-ray photoelectron spectroscopy (XPS). The modified with promoted osteoblast differentiation cell staining, viability, alkaline phosphatase activity, mineralization detection qRT-PCR osteogenesis-related genes. in vitro study exhibited properties after culturing S. aureus E. coli for 6 h 24 h. This demonstrates surface-modified implants can simultaneously promote bone growth provide capabilities.