Oral delivery of marine shellfish supramolecule peptides for skin wound healing

0301 basic medicine Mice Wound Healing 0303 health sciences 03 medical and health sciences Animals Peptides Hair Follicle Shellfish Skin 3. Good health
DOI: 10.1016/j.colsurfb.2022.112592 Publication Date: 2022-05-24T00:59:00Z
ABSTRACT
Oral administration of peptides/proteins with superior efficacy and fewer side effects is the most advantageous route of administration. In this study, we utilized controllable enzymatic (animal protease) hydrolysis technology to prepare active polypeptide self-assembling supramolecular (APs) from marine shellfish meat to explore the functional mechanism of APs in in vitro and in vivo (oral administration) experiments . In vitro experiments revealed that APs with self-assembly tendency had multifunctional activities. In vivo experiments indicated that oral administration of naturally safe APs could inhibited inflammation, promoted fibroblast proliferation and revascularization, and accelerated the epithelialization process, thus favoring a balanced repair tissue collagen I/III ratio and the promotion of hair follicle regeneration to achieve scarless healing, which was also relevant to "skin-gut" axis. These results showed that APs, as demonstrated in this study, promoted dermal wound healing in mice and may be developed and used to treat skin wounds.
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