Enhanced corrosion resistance in an inflammatory environment and osteogenic properties of silicalite-1 coated titanium alloy implants

• DOI: 10.1016/j.colsurfb.2022.112922
• Publication Date: 2022-10-15T07:06:27Z
• Authors: Junyan Wang; Mingrui Li; Ruining Shi; Shihui Yang; Jingjie Zhang; Duo Sun; Xiao Han; Zhe Zhou; Weijia Gao; Jinghui Zhao
• Keywords: Corrosion; Titanium; 03 medical and health sciences; 0302 clinical medicine; Coated Materials, Biocompatible; Osteogenesis; Surface Properties; Materials Testing; Alloys; 02 engineering and technology; 0210 nano-technology

The corrosion resistance and osteogenic property of titanium-based implants are crucial for their clinical application. Although they have good stability in standard physiological solutions, limited corrosion resistance in the inflammatory environment is still an unavoidable problem. Herein, the calcined and uncalcined silicalite-1 coatings were synthesized on titanium alloy (Ti-6Al-4 V). The corrosion resistance was investigated by simulating an inflammatory environment in vitro, and osteogenic potential was also evaluated. Here, the uncalcined silicalite-1 coating had the highest corrosion protection efficiency (PE) for Ti-6Al-4 V, which inhibited the metal ion release, surface damage and mass loss in the short-term (7 days) and long-term (30 days). Moreover, positive cell responses, including adhesion, proliferation and osteogenic differentiation of MC3T3-E1 cells, were observed in the uncalcined silicalite-1 coating system, supporting its favorable biocompatibility and osteogenic property. Therefore, these findings indicate that the uncalcined silicalite-1 may be a promising coating strategy for the surface modification of Ti-6Al-4 V implants.