The domain-variant indirect association between electrophysiological response to reward and ADHD presentations is moderated by dopaminergic polymorphisms

• DOI: 10.1016/j.comppsych.2023.152389
• Publication Date: 2023-04-23T23:06:05Z
• Authors: N. Bunford; Gy Hámori; Z. Nemoda; N. Angyal; R. Fiáth; T.É. Sebők-Welker; B. Pászthy; I. Ulbert; J.M. Réthelyi
• Keywords: Anticipation (artificial intelligence); Association (psychology)

Understanding the etiopathogenesis of attention-deficit/hyperactivity disorder (ADHD) may necessitate decomposition heterogeneous clinical phenotype into more homogeneous intermediate phenotypes. Reinforcement sensitivity is a promising candidate, but exact nature ADHD-reward relation – including how, for whom, and to which ADHD dimensions atypicalities in reward processing are relevant equivocal. Aims were examine, carefully phenotyped sample adolescents (N = 305; Mage 15.30 years, SD 1.07; 39.7% girls), whether functional dopaminergic polymorphisms implicated both (1) differentially associated with event-related potentials (ERPs) anticipation at distinct levels risk (nno 174, nat-risk 131, ndiagnosed 83); (2) moderate indirect effect dispositional affectivity on association between ERPs domains. In at-risk or ADHD, carrying hypodopaminergic allele was enhanced attention allocation cue attenuated anticipatory feedback. No associations observed not without ADHD. Controlling age sex, negative positive (PA) inattention PA hyperactivity/impulsivity supported only those high activity dopamine transporter (DAT) alleles. Reward affective phenotypes disentangling developmental pathways. Consistent multifinality, through successive effects affectivity, variants confer protection against hyperactivity/impulsivity.