A randomized controlled trial of exercise to prevent muscle mass and functional loss in elderly hemodialysis patients: Rationale, study design, and baseline sample

• DOI: 10.1016/j.conctc.2019.100365
• Publication Date: 2019-04-19T15:12:04Z
• Authors: Khin N. Chan; Yu Chen; Yiming Lit; Payam Massaband; Jenny Kiratli; Ralph Rabkin; Jonathan N. Myers
• Keywords: Aerobic Exercise; Hand strength

Elderly maintenance hemodialysis (MHD) patients exhibit muscle wasting and impaired physical function. This trial determines whether MHD benefit from a 12-week home-based exercise program, protein supplementation, or both.and Methods: is randomized, blinded controlled involving 60 elderly with capacity Patients are randomized into either homebased program normal care over period. Measures at baseline include peak VO2, strength body composition as well cognitive disease-specific questionnaires. Muscle biopsies obtained analyzed for signaling, expression of IGF-1, androgen receptors, myostatin.At baseline, patient characteristics in the groups were similar by age, gender anthropomorphic measures. Peak VO2 was (14.7 ± 3.3 ml/kg/min), representing 55 14% age-predicted value. Six-minute walk distance 322 71 m, mean 1-min sit to stand test 18 8 repetitions, 69 16% 22% values, respectively. Indices function, including upper lower hand grip all indicate marked impairment. Quality life (QoL) using SF36, Beeson test, KDQOL suggest impairments compared age-expected reference values non-MHD patients.Patients undergoing markedly reduced function QoL. Thus, there potentially significant gains be made through aerobic resistance exercise. We anticipate this will demonstrate that improves cardiopulmonary signaling QoL, increases mass, strength, composition.